Advise people to prevent partaking in dangerous responsibilities demanding psychological alertness and motor coordination immediately after ingestion of promethazine HCl and codeine phosphate oral Resolution. Stay away from concurrent utilization of promethazine HCl and codeine phosphate oral Alternative with alcohol or other central nervous process depressants since supplemental impairment of central nervous program functionality might come about [see Warnings and Precautions (five.ten)].
Discontinuation of a concomitantly employed cytochrome P450 2D6 inhibitor may possibly cause a lessen in codeine plasma concentration and a rise in Energetic metabolite morphine plasma focus which could improve or extend adverse reactions and will lead to likely lethal respiratory depression.
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Position the combination in a container like a sealed plastic bag and toss it absent during the family trash. You can even follow your point out or local pointers on how to properly toss away Promethazine Hydrochloride and Codeine Phosphate Oral Solution.
Simply call your healthcare provider or get emergency professional medical enable right away if any person using Promethazine with Codeine Oral Answer, or your breastfeeding newborn has any with the indications below: enhanced sleepiness
Prevent using promethazine HCl and codeine phosphate oral Alternative in adolescents twelve to eighteen years of age who produce other threat things which could maximize their sensitivity to your respiratory depressant effects of codeine.
Low hypertension. A sudden drop in hypertension can take place in a number of people for the duration of therapy with Promethazine Hydrochloride and Codeine Phosphate Oral Answer which could cause you to sense dizzy, faint, lightheaded, or weak, especially when you stand up (orthostatic hypotension). Your possibility of getting this problem could possibly be elevated if you take Promethazine Hydrochloride and Codeine Phosphate Oral Remedy with specified other medicines that lower hypertension.
Endocrine/Metabolic: Conditions of serotonin syndrome, a likely lifetime-threatening problem, have already been reported all through concomitant use of opioids with serotonergic drugs.
MAOI Interaction Advise sufferers not to just take promethazine HCl and codeine phosphate oral Remedy though employing or inside fourteen times of halting any medications that inhibit monoamine oxidase.
five.21 Drug/Laboratory Test Interactions Because opioid agonists may possibly increase biliary tract stress, with resultant rise in plasma amylase or lipase concentrations, perseverance of such enzyme ranges may very well be unreliable for twenty-four several hours right after administration of the dose of promethazine HCl and codeine phosphate oral Answer.
Drug interactions, like a heightened incidence of extrapyramidal consequences, happen to be reported when some MAOI and phenothiazines are used concomitantly.
2.1 Important Dosage and Administration Directions Administer promethazine HCl and codeine phosphate oral Answer by the oral route only. Always use an precise milliliter measuring product when administering promethazine HCl and codeine phosphate oral Remedy to ensure that the dose is measured and administered correctly.
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In sufferers with circulatory shock, promethazine HCl and codeine phosphate oral Answer may lead to vasodilation which will additional decrease cardiac output and hypertension. Stay clear of the usage of promethazine HCl and codeine phosphate oral Alternative in individuals with circulatory shock.